In Situ Product Recovery of Bio-Based Industrial Platform Chemicals: A Guideline to Solvent Selection
نویسندگان
چکیده
In situ product recovery (ISPR), in the form of an extractive fermentation process, can increase productivity and titers sustainable production platform chemicals. To establish a guideline for development industrially relevant processes such bio-based compounds, wide screening was performed, mapping potential extensive range solvents solvent mixtures. Besides biocompatibility with Saccharomyces cerevisiae, distribution coefficients three organic acids (protocatechuic acid, adipic acid para-aminobenzoic acid) four fragrance compounds (2-phenylethanol, geraniol, trans-cinnamaldehyde ?-ionone) were determined. While highly hydrophobic multiple pure identified that able to extract more than 98%, reactive extraction mixtures proven effective challenging including hydrophilic alcohols. For example, mixture consisting 12.5% extractant CYTOP 503 canola oil found be biocompatible showed superior efficiency as compared any single solvent. This various classes industrial chemicals tremendous step forward fermentations.
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ژورنال
عنوان ژورنال: Fermentation
سال: 2021
ISSN: ['2311-5637']
DOI: https://doi.org/10.3390/fermentation7010026